Immortalized Cell Lines

Immortalized cell lines are populations of cells that can divide indefinitely and be grown for extended periods in a laboratory setting. They are created by altering the cells' genes to overcome the Hayflick limit, which is the number of times a somatic cell can divide before it loses the ability to proliferate.

Immortalized cell lines are useful for research because they are:

Consistent: They grow consistently and can be reproduced. Cost-effective: They are easier to culture than other cells.

Homogeneous: They are theoretically identical populations.

Unlimited: They provide an unlimited source of cells for research.

Immortalized cell lines can be derived from cells with chromosomal abnormalities or mutations, such as tumors. They can also be created by artificially manipulating cells to proliferate indefinitely. Some methods for immortalizing cells include:

Over-expressing viral genes: For example, the large T-antigen of the simian virus (SV40) or human telomerase reverse transcriptase (hTERT)

Using the Epstein–Barr Virus (EBV): This virus infects B lymphocytes and can immortalize them.

Immortalized Cell Lines from Runtogen were derived from primary cells with extended life span. The primary cells were immortalized by over-expression of the large T-antigen of the simian virus (SV40) or human telomerase reverse transcriptase (hTERT). Runtogen has developed 80+ kinds of immortalized cell lines, including Human immortalized cells, Rat immortalized cells, Dog immortalized cells, Porcine immortalized cells, Chicken immortalized cells and Mouse immortalized cells, etc. We also provides Custom Cell Immortalization Service for your unique solutions. For details regarding this special service, please contact us at [email protected]. We will contact you promptly within 24h.

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